Season 6
EPISODE 01 - (EXILE ON MAIN STREET)
MITCH PILEGGI ("X-Files," "Sons of Anarchy") RETURNS AS DEAN AND SAM'S GRANDFATHER - It's a year later and Dean (Jensen Ackles) has given up hunting and is living with Lisa (guest star Cindy Sampson) and her son Ben (guest star Nicholas Elia). Mysteriously freed from his cage in hell, Sam (Jared Padalecki) finds Dean and tells him he needs to rejoin the fight and introduces Dean to a world-a family-he never even knew existed: the Campbells, his mother's family, lead by none other than their Grandfather Samuel (Pileggi).
EPISODE 02 - (TWO AND A HALF MEN)
SAMUEL CREATES CONFLICT BETWEEN DEAN AND SAM - Sam (Jared Padalecki) investigates a case about missing babies whose parents are being murdered. At one of the crime scenes, he discovers a baby that was left behind and calls Dean (Jensen Ackles) for help. Reluctant to leave Lisa (guest star Cindy Sampson) and Ben (guest star Nicholas Elia), Dean finally agrees to meet Sam and surprises his brother with how parental he has become. The brothers take the baby to Samuel (guest star Mitch Pileggi), who decides to raise it as a hunter, which infuriates Dean. However, before they can decide the baby's future, a shape-shifter breaks in and attempts to kidnap the baby.
EPISODE 03 - (THE THIRD MAN)
CASTIEL RETURNS - Sam (Jared Padalecki) and Dean (Jensen Ackles) call Castiel (Misha Collins) for help when they investigate a case about several dead police officers who seem to have been killed by the plagues of Egypt. Castiel confirms the staff of Moses was used to kill the cops and tells Sam and Dean that Heaven is in a state of chaos and God's weapons have been stolen. The three head off to find the thief and come face to face with an old enemy.
EPISODE 04 - (WEEKEND AT BOBBY'S)
JENSEN ACKLES' DIRECTORIAL DEBUT - After Bobby (Jim Beaver) discovers Crowley (guest star Mark Sheppard) has no intentions of returning Bobby's soul, the hunter takes matters into his own hands. He calls on Sam (Jared Padalecki) and Dean (Jensen Ackles) for help after he unearths one of Crowley's deepest secrets. Meanwhile, Sam and Dean learn what Bobby does all day when they are not around.
EPISODE 05 - (LIVE FREE OR TWIHARD)
DEAN IS TURNED INTO A VAMPIRE - After a group of young girls go missing, Sam (Jared Padalecki) and Dean (Jensen Ackles) realize that a group of vampires have taken up residence in the small town. After a fight with two of the blood-suckers, Dean is bitten and turns into a vampire. Samuel (guest star Mitch Pileggi) tells Dean he can change him back but he'd have to get the blood of the vampire who turned him. Dean infiltrates the nest and runs into the Alpha.
EPISODE 06 - (YOU CAN'T HANDLE THE TRUTH)
THE TRUTH HURTS - Sam (Jared Padalecki) and Dean (Jensen Ackles) investigate a series of suicides and discover the victims were being told brutal truths that drove them crazy. They find out someone is invoking the Goddess of Truth, Veritas, forcing people to be cruelly honest against their will and Dean is the next victim. Dean is forced to tell Sam the truth about how he feels about his return from Hell.
EPISODE 07 - (FAMILY MATTERS)
DOES SAMUEL HAVE A SECRET? - Dean (Jensen Ackles) becomes suspicious of Samuel's (guest star Mitch Pileggi) motives, but Sam isn't sold on the idea that their grandfather is doing anything wrong. The brothers go along on a hunt with Samuel and the other Campbells, but things go terribly awry.
EPISODE 08 - (ALL DOGS GO TO HEAVEN)
IT'S A DOG'S LIFE - Dean (Jensen Ackles) and Sam (Jared Padalecki) investigate what seems to be a werewolf killing but turns out to be a skinwalker (guest star Andrew Rothenberg) posing as a family dog who is taking revenge on his owner's enemies. After capturing the dog, he turns human and tells Sam and Dean that an Alpha skinwalker has created many sleeper cells that will rise on his command and kill their families. The only way to stop the mass murders is to find and kill the Alpha.
EPISODE 09 - (CLAP YOUR HANDS IF YOU BELIEVE)
FAIRIES! - While Sam (Jared Padalecki) and Dean (Jensen Ackles) are investigating a UFO sighting, Dean is abducted from a crop circle. However, when he awakens, he discovers he isn't dealing with aliens, but fairies! Unfortunately, only Dean can see the fairy that keeps attacking him which makes tracing and stopping them difficult. The brothers become even more perplexed when Sam's investigation leads them to a world full of elves, gnomes and a leprechaun.
EPISODE 10 - (CAGED HEAT)
MEG'S BACK! - Meg (guest star Rachel Miner) kidnaps Sam (Jared Padalecki) and Dean (Jensen Ackles) and tries to force them to tell her where Crowley (guest star Mark A. Sheppard) is hiding. Sam makes her a deal: they will help her find Crowley if she promises to torture him for information about how to get Sam's soul back. Castiel (Misha Collins) joins the fight but finds it difficult to work with Meg.
EPISODE 11 - (APPOINTMENT IN SAMARRA)
DEATH RETURNS FOR A MEETING WITH DEAN - Dean (Jensen Ackles) seeks out Death (guest star Julian Richings) to help get Sam's (Jared Padalecki) soul back. Death tells Dean he will help Sam if Dean will agree to act as Death for 24 hours. Meanwhile, Sam decides he doesn't want his soul back and asks Balthazar (guest star Sebastian Roché) for a protective spell to keep his soul out of his body. Balthazar tells Sam he needs the blood of his father for the spell to work and since John Winchester is dead, Sam decides Bobby (Jim Beaver) is the next best thing.
EPISODE 12 - (LIKE A VIRGIN)
DEATH RETURNS FOR A MEETING WITH DEAN - Dean (Jensen Ackles) and Bobby (Jim Beaver) anxiously wait for Sam (Jared Padalecki) to wake up to see if Death (guest star Julian Richings) was able to restore his soul without causing Sam to lose his mind. Meanwhile, Dean and Bobby investigate a disappearance of virgins and discover dragons are behind the kidnappings. Bobby sends Dean to a doctor who owns the only weapon in the world that can slay a dragon, but Dean must prove himself worthy enough to take it.
EPISODE 13 - (UNFORGIVEN)
DEAN FINDS OUT ABOUT SAM'S LIFE WHEN HE HUNTED WITH SAMUEL - Sam (Jared Padalecki) starts to have flashbacks to a case he worked on with Samuel (guest star Mitch Pileggi) before he reconnected with Dean (Jensen Ackles). Sam receives a mysterious text with coordinates to a small town, so the brothers decide to investigate. Dean is surprised when the townspeople start telling him some of the things Sam did while he lived there.
EPISODE 14 - (MANNEQUIN 3: THE RECKONING)
DEAN RUSHES HOME TO CHECK ON LISA - Ben (guest star Nicolas Elia) calls Dean (Jensen Ackles) and tells him Lisa (guest star Cindy Sampson) is in trouble. Dean leaves Sam (Jared Padalecki) to investigate a case alone and rushes home to rescue Lisa, however, he's not prepared for what meets him at the door. Meanwhile, Sam discovers the men that were murdered were all a part of a cruel practical joke played on a female co-worker who went missing.
EPISODE 15 - (THE FRENCH MISTAKE)
SAM AND DEAN ARE TRANSPORTED TO AN ALTERNATE REALITY - Raphael (guest star Lanette Ware) launches an attack on Castiel (Misha Collins) and his allies, sending a particularly frightening angelic hitman (guest star Carlos Sanz) after Balthazar (guest star Sebastian Roché), Sam (Jared Padalecki) and Dean (Jensen Ackles). In an effort to protect the brothers, Balthazar sends them to an alternate universe where they are the stars of a TV show called "Supernatural" and they are actors named "Jensen Ackles" and "Jared Padalecki." The brothers are confused when Castiel appears to be a tweet-happy actor named "Misha Collins" and Sam is married to Ruby (Genevieve Cortese).
EPISODE 16 - (...AND THEN THERE WERE NONE)
SAMUEL JOINS UP WITH SAM AND DEAN - Sam (Jared Padalecki), Dean (Jensen Ackles) and Bobby (guest star Jim Beaver) set out in search of The Mother of All's latest monster. While investigating, they run into Samuel (guest star Mitch Pileggi) and Gwen (guest star Jessica Heafey), who are also hunting the creature. Samuel and Bobby get into a heated fight about how to handle the case.
EPISODE 17 - (MY HEART WILL GO ON)
SAM AND DEAN TEMPT FATE - After Balthazar (guest star Sebastian Roché) changes history and keeps the Titanic from sinking, Fate (guest star Katie Walder) intervenes and begins killing those that would have died on the ship. Castiel (Misha Collins) tells Sam (Jared Padalecki) and Dean (Jensen Ackles) that Fate is very upset with the two of them and the only way they can stay alive is to kill her.
EPISODE 18 - (FRONTIERLAND)
SAM AND DEAN RETURN TO THE WILD, WILD WEST - While searching for a way to defeat Eve, Dean (Jensen Ackles) stumbles upon Samuel Colt's (guest star Sam Hennings) journal in the Campbell library. Realizing Samuel might have the answer to their problems, Sam (Jared Padalecki) and Dean ask Castiel (Misha Collins) to send them back in time so they can meet the man himself. While Sam is a bit reluctant to time travel, Dean is beside himself with excitement to return to the Wild, Wild West.
EPISODE 19 - (MOMMY DEAREST)
SAM AND DEAN MEET EVE - Sam (Jared Padalecki), Dean (Jensen Ackles), Bobby (guest star Jim Beaver) and Castiel (Misha Collins) track Eve (guest star Julia Maxwell) to a small town in Oregon. The guys discover the townspeople have been converted to demons, but surprisingly, they all appear to be dying. When they finally do meet Eve, she decides to torture the brothers by bringing back their mother, Mary Winchester (guest star Samantha Smith), as a demon.
EPISODE 20 - (THE MAN WHO WOULD BE KING)
EXECUTIVE PRODUCER BEN EDLUND WROTE AND DIRECTED THE EPISODE - Castiel (Misha Collins) tells Sam (Jared Padalecki), Dean (Jensen Ackles) and Bobby (guest star Jim Beaver) about the war in Heaven and how he and Raphael became enemies. Bobby believes Castiel is hiding something, but Dean refuses to believe it.
EPISODE 21 - (LET IT BLEED)
DEAN'S WORST NIGHTMARE COMES TRUE - A demon kidnaps Ben (guest star Nicholas Elia) and Lisa (guest star Cindy Sampson) to get to Dean (Jensen Ackles). Sam (Jared Padalecki) and Dean are forced to join with an unlikely ally to free them.
EPISODE 22 - (THE MAN WHO KNEW TOO MUCH)
EXECUTIVE PRODUCER ERIC KRIPKE PENS THE SEASON FINALE - The wall comes down in Sam's (Jared Padalecki) head and all hell breaks loose. Dean (Jensen Ackles) and Bobby (guest star Jim Beaver) are, for once, at a total loss on how to help him and are forced to stand by and do nothing while Sam breaks. The battle for heaven comes to a head.