Supernatural (Season 1)

 After their mother's death in a suspicious fire that burns down their house 22 years prior, Sam and Dean Winchester's father goes missing during a "hunting trip". As a result, Dean tracks down Sam at Stanford University. The two brothers live a life on the road, in Dean's black, 1967 Chevrolet Impala with Kansas license plates. However, their father is not a typical hunter: he hunts supernatural creatures like ghosts, vampires, and spirits, and has trained his sons to do the same. Along the way, Sam and Dean save innocent people, fight creatures and ghosts, and collect clues to their father's whereabouts. Sam begins to mysteriously develop psychic abilities and visions as they travel. They also find another man with abilities similar to Sam's, whose mother died the same way. They reach out to the young man, Max Miller, offering help and seeking answers. But Max has experienced years of physical abuse and neglect and his life ends in a murder suicide which Dean and Sam are unable to stop. They eventually find and reunite with their father, who reveals that the creature that killed their mother years earlier is the demon Azazel (aka "Yellow Eyes") and the only thing that can kill him is a legendary gun created by Samuel Colt. The season ends with the brothers and their father involved in a car crash when a truck hits the side of the Impala. They lie inside the car, covered in blood and unconscious.